Effects of annealing and the addition of PEG on the PVA based hydrogel by gamma ray

被引：40

作者：

Park, Jong-Seok ^{[1
]}

Kim, Hyun-A ^{[1
]}

Choi, Jong-Bae ^{[1
]}

Gwon, Hui-Jeong ^{[1
]}

Shin, Young-Min ^{[1
]}

Lim, Youn-Mook ^{[1
]}

Khil, Myung Seob ^{[2
]}

Nho, Young-Chang ^{[1
]}

机构：

[1] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 580185, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Dept Organ Mat & Fibers Engn, Jeonju 561756, South Korea

来源：

RADIATION PHYSICS AND CHEMISTRY | 2012年 / 81卷 / 07期

关键词：

Poly(vinyl alcohol); Poly(ethylene glycol); Hydrogels; Annealing; Irradiation; CROSS-LINKING; PHYSICAL-PROPERTIES; RADIATION; PEPTIDE;

D O I：

10.1016/j.radphyschem.2012.02.005

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Poly(vinyl alcohol) (PVA) is an interesting material with good biocompatibility, high elasticity and hydrophilic characteristics. PVA hydrogels have been formed through chemical crosslinking with aldehyde, photopolymerization and physical crosslinking with freeze-thawing. In this study, crosslinked hydrogels based on PVA, and poly(ethylene glycol) (PEG) were prepared by gamma-ray irradiation, and then annealed at 120 degrees C. The properties of a hydrogel such as gel fraction, swelling behavior, gel strength as a function of PEG content and annealing time were investigated. Also, the thermal behaviors were examined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The gel fraction decreases with an increase in PEG content and decrease in annealing time. The tensile strength increases with an increase in annealing time. The thermal behaviors have shown different patterns according to the annealing time. The improved properties suggest that PVA/PEG blend hydrogel can be a good candidate for applications in the articular cartilage. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：857 / 860

页数：4

共 16 条

[1] Humectants effect on aqueous fluids absorption of γ-irradiated PVA hydrogel followed by freeze thawing [J].

Gwon, Hui-Jeong ;

Lim, Youn-Mook ;

Nho, Young-Chang ;

Baik, Sang-Ho .

RADIATION PHYSICS AND CHEMISTRY, 2010, 79 (05) :650-653

[2]

Hassan CM, 2000, ADV POLYM SCI, V153, P37

[3]

Krishnan B.R., 2002, ADV DRUG DELIV REV, V43, P3

[4] Direct UV photocrosslinking of poly(N-vinyl-2-pyrrolidone) (PVP) to produce hydrogels [J].

Lopérgolo, LC ;

Lugao, AB ;

Catalani, LH .

POLYMER, 2003, 44 (20) :6217-6222

[5] Rheological behaviour of irradiated wound dressing poly(vinyl pyrrolidone) hydrogels [J].

Lugao, AB ;

Rogero, SO ;

Malmonge, SM .

RADIATION PHYSICS AND CHEMISTRY, 2002, 63 (3-6) :543-546

[6] Synthesis of PVA/PVP hydrogels having two-layer by radiation and their physical properties [J].

Park, KR ;

Nho, YC .

RADIATION PHYSICS AND CHEMISTRY, 2003, 67 (3-4) :361-365

[7] Preparation of poly(polyethylene glycol methacrylateco-acrylic acid) hydrogels by radiation and their physical properties [J].

Park, SE ;

Nho, YC ;

Kim, HI .

RADIATION PHYSICS AND CHEMISTRY, 2004, 69 (03) :221-227

[8] PVA hydrogel sheet macroencapsulation for the bioartificial pancreas [J].

Qi, M ;

Gu, Y ;

Sakata, N ;

Kim, D ;

Shirouzu, Y ;

Yamamoto, C ;

Hiura, A ;

Sumi, S ;

Inoue, K .

BIOMATERIALS, 2004, 25 (27) :5885-5892

[9] Chemistry for peptide and protein PEGylation [J].

Roberts, MJ ;

Bentley, MD ;

Harris, JM .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (04) :459-476

[10] Hydrogels and their medical applications [J].

Rosiak, JM ;

Yoshii, F .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1999, 151 (1-4) :56-64

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