Dynamic Organization of Chromatin Assembly and Transcription Factories in Living Cells

被引：7

作者：

Sinha, Bidisha ^{[1
]}

Bhattacharya, Dipanjan ^{[1
]}

Sinha, Deepak Kumar ^{[1
]}

Talwar, Shefali ^{[1
,2
,3
]}

Maharana, Shovamayee ^{[1
,2
,3
]}

Gupta, Soumya ^{[1
,2
,3
]}

Shivashankar, G. V. ^{[1
,2
,3
]}

机构：

[1] Tata Inst Fundamental Res, Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

[3] Natl Univ Singapore, Res Ctr Excellence MechanoBiol, Singapore 117543, Singapore

来源：

NUCLEAR MECHANICS AND GENOME REGULATION | 2010年 / 98卷

关键词：

NUCLEOSOME CORE; HISTONE H1; CHROMOSOME TERRITORIES; NUCLEAR ARCHITECTURE; MAMMALIAN-CELLS; GENE-EXPRESSION; RAPID EXCHANGE; STEM-CELLS; BINDING; DIFFERENTIATION;

D O I：

10.1016/S0091-679X(10)98003-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The interphase nucleus is an active organelle involved in processing genetic information. In higher order eukaryotes, information control is compartmentalized - for example at the scale of inter-chromosome territories and nuclear bodies. Regulatory proteins, nuclear bodies and chromatin assembly are found to be highly dynamic within the nucleus of primary cells and through cellular differentiation programs. In this chapter we describe live-cell fluorescence based techniques and single particle tracking analysis, to probe the spatio-temporal dimension in nuclear function.

引用

页码：57 / 78

页数：22

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