Morphology and Surface Properties of Poly (L-lactic acid)/Captopril Composite Nanofiber Membranes

被引：1

作者：

Wei, Anfang ^{[1
]}

Wang, Juan ^{[2
]}

Wang, Xueqian ^{[3
]}

Hou, Dayin ^{[3
]}

Wei, Qufu ^{[1
]}

机构：

[1] Jiangnan Univ, Key Lab Ecotext, Wuxi 214122, Jiangsu, Peoples R China

[2] Wannan Med Coll, Wuhu 241002, Anhui, Peoples R China

[3] Anhui Polytech Univ, Wuhu 241000, Anhui, Peoples R China

来源：

JOURNAL OF ENGINEERED FIBERS AND FABRICS | 2012年 / 7卷 / 01期

基金：

中国国家自然科学基金;

关键词：

POLY(LACTIC ACID); CAPTOPRIL; RELEASE; FIBER;

D O I：

10.1177/155892501200700115

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

In this study, Poly (L-lactic acid)/Captopril composite nanofiber membranes were electrospun for drug delivery. Different mass fractions of Poly (L-lactic acid), different ratios of Captopril and the influences of PEG4000 added in the spinning solution are discussed. The morphology, chemical components, the surface areas and pore sizes, wettability of the composite nanofiber membranes were investigated. The results showed that the diameters of the composite nanofibers increased with the increase of Poly (L-lactic acid) mass fractions, the diameters decreased with the increase of Captopril content as well as the addition of the surfactant. Fourier Transform Infrared (FT-IR) showed the chemical components of Captopril remained unchanged when it was electrospun into the composite nanofibers. The surface areas pore width and pore volume of the composite nanofibers became a little larger than those of poly (L-lactic acid) nanofibers, and the wettability of the composite nanofiber membranes was better than those of poly (L-lactic acid) nanofiber membranes. Wettability was improved by an increase of the drug load amount.

引用

页码：129 / 135

页数：7

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