The Influence of Zwitterionic Phospholipid Brushes Grafted via UV-Initiated or SI-ATR Polymerization on the Hemocompatibility of Polycarbonateurethane

被引：17

作者：

Feng, Yakai ^{[1
,2
]}

Yang, Dazhi ^{[1
]}

Behl, Marc ^{[2
,3
]}

Lendlein, Andreas ^{[2
,3
]}

Zhao, Haiyang ^{[1
]}

Guo, Jintang ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Univ Helmholtz Zentrum Geesthach, Joint Lab Biomat & Regenerat Med, D-14513 Teltow, Germany

[3] Helmholtz Zentrum Geesthacht, Inst Polymer Res, Ctr Biomat Dev, Berlin BCRT, D-14513 Teltow, Germany

来源：

ADVANCED POLYMERS IN MEDICINE | 2011年 / 309-310卷

关键词：

ATRP; hemocompatibility; phosphorylcholine; polycarbonateurethane; surface modification; UV grafting; PROTEIN ADSORPTION; PLATELET-ADHESION; BIOMEDICAL APPLICATIONS; POLY(ETHYLENE GLYCOL); SURFACE MODIFICATION; STRONG RESISTANCE; POLYURETHANE; PHOSPHORYLCHOLINE; POLYMERS; BIOMATERIALS;

D O I：

10.1002/masy.201100034

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Biomimetic phosphorylcholine (PC) groups were introduced onto material surfaces in order to improve the hydrophilicity and in this way the hemocompatibility of polycarbonateurethanes (PCUs). Surface-initiated atom transfer radical polymerization (SI-ATRP) of 2-methacryloyloxyethyl phosphorylcholine (MPC) initiated by irradiation with ultraviolet (UV) light created polymer brushes having PC side groups. Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), scanning electrical microscopy (SEM) and water contact angle were used to characterize the chemical and physical properties of the modified PCU surfaces. The PC-grafted PCU surfaces showed a significantly higher hydrophilicity as indicated by low water contact angles when compared with original PCU. The in vitro hemocompatibility of the PC-grafted PCU surfaces was evaluated by platelet adhesion tests. The PCU surfaces modified with phosphorylcholine zwitterionic brushes showed effective resistance for platelet adhesion and high hemocompatibility. These PC-grafted PCU materials might be potentially applied in blood-contacting materials or devices due to their good mechanical and hemocompatible properties.

引用

页码：6 / 15

页数：10