Central lactate metabolism regulates food intake

被引：61

作者：

Lam, Carol K. L. ^{[1
,3
]}

Chari, Madhu ^{[1
,3
]}

Wang, Penny Y. T. ^{[3
]}

Lam, Tony K. T. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Toronto, ON, Canada

[3] Toronto Gen Hosp, Res Inst, Univ Hlth Network, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2008年 / 295卷 / 02期

关键词：

central nervous system; obesity; diabetes;

D O I：

10.1152/ajpendo.90481.2008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with the lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW.

引用

页码：E491 / E496

页数：6

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