t(8;20)(q22;p13): a novel variant translocation of t(8;21) in acute myeloblastic leukaemia

被引:18
作者
Xue, YQ
Yu, F
Xin, YN
Lu, D
Zou, ZH
Guo, Y
Xie, X
机构
[1] SUZHOU MED COLL,AFFILIATED HOSP 2,SUZHOU,PEOPLES R CHINA
[2] FUDAN UNIV,INST GENET,SHANGHAI 200433,PEOPLES R CHINA
基金
新加坡国家研究基金会;
关键词
acute myeloid leukaemia; 8; 21; translocation; variant translocation; fusion gene; reverse transcriptase polymerase chain reaction;
D O I
10.1046/j.1365-2141.1997.2693088.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A novel Variant translocation t(8;20)(q22;p13) detected by karyotype analysis of bone marrow cells using Rand G-banding techniques, is reported in a case of M2-acute myeloid leukaemia (AML). The leukaemic cells were indistinguishable morphologically from that of M2-AML with t(8;21)translocation. RT-PCR revealed no AML1/ETO fusion transcript, but the wild-type ETO-3' was expressed in the bone marrow cells suggesting that t(8;20) is a true simple Variant translocation of t(8;21), and that a fusion gene consisting of ETO and an unidentified gene located in band 20p13 mag exist in our case. Further study is required to clarify the entity of the assumed fusion gene.
引用
收藏
页码:733 / 735
页数:3
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