Abnormal perfusion in patellofemoral subchondral bone marrow in the rat anterior cruciate ligament transection model of post-traumatic osteoarthritis: a dynamic contrast-enhanced magnetic resonance imaging study

被引：14

作者：

Tsai, P. -H. ^{[1
,2
,3
,4
]}

Lee, H. -S. ^{[5
,6
]}

Siow, T. Y. ^{[7
,8
]}

Wang, C. -Y. ^{[1
,9
]}

Chang, Y. -C. ^{[10
]}

Lin, M. -H. ^{[8
]}

Hsu, Y. -C. ^{[1
]}

Lee, C. -H. ^{[11
]}

Chung, H. -W. ^{[12
]}

Huang, G. -S. ^{[1
,13
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Radiol, Taipei 114, Taiwan

[2] Taipei Med Univ, Coll Med, Sch Med, Dept Radiol, Taipei, Taiwan

[3] Taipei Med Univ, Taipei Med Univ Hosp, Dept Med Imaging, Taipei, Taiwan

[4] Taipei Med Univ, Taipei Med Univ Hosp, Translat Imaging Res Ctr, Taipei, Taiwan

[5] Kaohsiung Vet Gen Hosp, Dept Pathol & Lab Med, Kaohsiung, Taiwan

[6] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Taipei 114, Taiwan

[7] Chang Gung Univ, Chang Gung Mem Hosp Linkou, Dept Med Imaging & Intervent, Inst Radiol Res,Coll Med, Taoyuan, Taiwan

[8] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[9] Natl Def Med Ctr, Dept & Grad Inst Biol & Anat, Taipei, Taiwan

[10] Tamkang Univ, Dept Math, Taipei, Taiwan

[11] Taipei Med Univ & Hosp, Coll Med, Sch Med, Dept Orthoped, Taipei, Taiwan

[12] Natl Taiwan Univ, Grad Inst Biomed Elect & Bioinformat, Taipei 10764, Taiwan

[13] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, Taipei 114, Taiwan

来源：

OSTEOARTHRITIS AND CARTILAGE | 2016年 / 24卷 / 01期

关键词：

Post-traumatic osteoarthritis; Patellofemoral joint; Anterior cruciate ligament; DCE-MRI; Perfusion; Subchondral bone marrow; KNEE OSTEOARTHRITIS; AVASCULAR NECROSIS; RECONSTRUCTION; INJURY; PAIN;

D O I：

10.1016/j.joca.2015.07.015

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Design: Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee. Perfusion parameters in the patellar and femoral subchondral bone marrows of all rats were measured on DCE-MRI at 0, 4, 8, and 16 weeks after respective treatment. After the last MRI at week 16, the rats were sacrificed and their right knees were harvested for histologic examination. In addition, to observe the long-term histologic change in PF joints, 9 additional rats (n = 3 in each group) were included and sacrificed at week 32 for histologic examination. Results: In the ACLX group vs the sham and control groups, the perfusion parameters were significantly changed in both patellar and femoral subchondral bone marrows at week 16. Histologic examination revealed cartilage defects in ACLX rats at 32 weeks after surgery. Conclusions: These data point to a possible functional relationship between subchondral bone marrow perfusion abnormalities and cartilage breakdown in PTOA. Moreover, the perfusion parameters derived from DCE-MRI can potentially serve as biomarkers of early OA. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：129 / 133

页数：5

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