Graphene based chalcogenide fiber-optic evanescent wave sensor for detection of hemoglobin in human blood

被引:33
作者
Sharma, Anuj K. [1 ]
Gupta, Jyoti [2 ]
机构
[1] Natl Inst Technol Delhi, Dept Appl Sci, Phys Div, Delhi 110040, India
[2] Natl Inst Technol Delhi, Dept Elect & Commun Engn, Delhi 110040, India
关键词
Optical fiber; Hemoglobin; Sensor; Graphene; Evanescent; SURFACE-PLASMON RESONANCE; ABSORPTION SENSOR; MONOLAYER GRAPHENE; REFRACTIVE-INDEX; SPECTROSCOPY; COEFFICIENT; SIMULATION; GLASS;
D O I
10.1016/j.yofte.2018.01.012
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Fiber optic evanescent wave sensor with graphene as an absorption-enhancing layer to measure hemoglobin concentration in human blood is proposed. Previous modal functions and experimental results describing the variation of optical constants of human blood with different hemoglobin concentrations in the near-infrared spectral region are considered for sensor design simulation. The sensor's performance is closely analyzed in terms of its absorption coefficient, sensitivity, and detection limit. It is found that the proposed sensor should be operated at longer light wavelength to get more enhanced sensitivity and smaller detection limit. At 1000 nm wavelength, a detection limit of 18 mu g/dL and sensitivity of 6.71x10(-4) per g/dL is achievable with the proposed sensor. The sensitivity is found to be better for larger hemoglobin concentrations. The results are correlated with the evanescent wave penetration depth.
引用
收藏
页码:125 / 130
页数:6
相关论文
共 26 条
[1]   Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration [J].
Friebel, M ;
Meinke, M .
APPLIED OPTICS, 2006, 45 (12) :2838-2842
[2]   Graphene Enhances the Sensitivity of Fiber-Optic Surface Plasmon Resonance Biosensor [J].
Fu, Hongyan ;
Zhang, Shiwei ;
Chen, Hao ;
Weng, Jian .
IEEE SENSORS JOURNAL, 2015, 15 (10) :5478-5482
[3]  
Gupta B. D., 1993, International Journal of Optoelectronics, V8, P409
[4]   FIBEROPTIC EVANESCENT FIELD ABSORPTION SENSOR - A THEORETICAL EVALUATION [J].
GUPTA, BD ;
SINGH, CD .
FIBER AND INTEGRATED OPTICS, 1994, 13 (04) :433-443
[5]   EVANESCENT-ABSORPTION COEFFICIENT FOR DIFFUSE SOURCE ILLUMINATION - UNIFORM-FIBER AND TAPERED-FIBER SENSORS [J].
GUPTA, BD ;
SINGH, CD .
APPLIED OPTICS, 1994, 33 (13) :2737-2742
[6]  
Haija AJ, 2006, OPT APPL, V36, P39
[7]   Absorption-Modulated Crossed-Optical Fiber-Sensor Platform for Measurements in Liquid Environments and Flow Streams [J].
Henning, Paul E. ;
Geissinger, Peter .
JOURNAL OF SENSORS, 2017, 2017
[8]   Optical Fibre Sensors Using Graphene-Based Materials: A Review [J].
Hernaez, Miguel ;
Zamarreno, Carlos R. ;
Melendi-Espina, Sonia ;
Bird, Liam R. ;
Mayes, Andrew G. ;
Arregui, Francisco J. .
SENSORS, 2017, 17 (01)
[9]   Evanescent Wave Absorption Sensor Based Tapered Plastic Optical Fiber Coated with Monolayer Graphene for Ethanol Molecules Detection [J].
Jiang, Shouzhen ;
Qiu, Hengwei ;
Gao, Saisai ;
Chen, Peixi ;
Li, Zhen ;
Yu, Kaiyang ;
Yue, Weiwei ;
Yang, Cheng ;
Huo, Yanyan ;
Wang, Shuyun .
CHINESE JOURNAL OF CHEMISTRY, 2016, 34 (10) :1039-1047
[10]   Determination of bacterial activity by use of an evanescent-wave fiber-optic sensor [J].
John, MS ;
Kishen, A ;
Sing, LC ;
Asundi, A .
APPLIED OPTICS, 2002, 41 (34) :7334-7338