Osteoporotic fractures and hospitalization risk in chronic spinal cord injury

被引:150
作者
Morse, L. R. [1 ,2 ,3 ]
Battaglino, R. A. [4 ]
Stolzmann, K. L. [5 ,6 ]
Hallett, L. D. [5 ,6 ]
Waddimba, A. [5 ,6 ,8 ,12 ]
Gagnon, D. [5 ,7 ]
Lazzari, A. A. [5 ,9 ,10 ]
Garshick, E. [5 ,6 ,11 ,12 ]
机构
[1] Harvard Univ, Sch Med, Dept PMR, Forsyth Inst, Boston, MA 02118 USA
[2] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA 02215 USA
[3] Spaulding Rehabil Hosp, Boston, MA USA
[4] Forsyth Inst, Dept Cytokine Biol, Boston, MA USA
[5] VA Boston Healthcare Syst, Dept Vet Affairs, Res & Dev Serv, Boston, MA USA
[6] Harvard Univ, Sch Med, Programs Res VA Boston, Boston, MA 02118 USA
[7] Boston Univ, Sch Publ Hlth, VA Cooperat Studies Program, VA Boston Healthcare Syst,Dept Biostat, Boston, MA USA
[8] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA 02115 USA
[9] VA Boston Healthcare Syst, Div Primary Care, Rheumatol Sect, Osteoporosis Prevent Clin,Boston Div, Boston, MA USA
[10] Boston Univ, Sch Med, Boston, MA 02118 USA
[11] VA Boston Healthcare Syst, Med Serv, Pulm & Crit Care Med Sect, Boston, MA USA
[12] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA 02118 USA
关键词
Bone fracture; Hospitalization; Osteoporosis; Rehabilitation; Spinal cord injury; BONE-MINERAL DENSITY; ALCOHOL-CONSUMPTION; GROWING RATS; ALENDRONATE; METABOLISM; MORTALITY; VETERANS; HEALTH; LIFE; MASS;
D O I
10.1007/s00198-008-0671-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoporosis is a well acknowledged complication of spinal cord injury. We report that motor complete spinal cord injury and post-injury alcohol consumption are risk factors for hospitalization for fracture treatment. The clinical assessment did not include osteoporosis diagnosis and treatment considerations, indicating a need for improved clinical protocols. Treatment of osteoporotic long bone fractures often results in lengthy hospitalizations for individuals with spinal cord injury. Clinical features and factors that contribute to hospitalization risk have not previously been described. Three hundred and fifteen veterans a parts per thousand yen 1 year after spinal cord injury completed a health questionnaire and underwent clinical exam at study entry. Multivariate Cox regression accounting for repeated events was used to assess longitudinal predictors of fracture-related hospitalizations in Veterans Affairs Medical Centers 1996-2003. One thousand four hundred and eighty-seven hospital admissions occurred among 315 participants, and 39 hospitalizations (2.6%) were for fracture treatment. Median length of stay was 35 days. Fracture-related complications occurred in 53%. Independent risk factors for admission were motor complete versus motor incomplete spinal cord injury (hazard ratio = 3.73, 95% CI = 1.46-10.50). There was a significant linear trend in risk with greater alcohol consumption after injury. Record review indicated that evaluation for osteoporosis was not obtained during these admissions. Assessed prospectively, hospitalization in Veterans Affairs Medical Centers for low-impact fractures is more common in motor complete spinal cord injury and is associated with greater alcohol use after injury. Osteoporosis diagnosis and treatment considerations were not part of a clinical assessment, indicating the need for improved protocols that might prevent low-impact fractures and related admissions.
引用
收藏
页码:385 / 392
页数:8
相关论文
共 36 条
[1]  
BARREAU D, 1995, SIGCHI B, V27, P3
[2]   Risk-adjusted mortality rates of elderly veterans with hip fractures [J].
Bass, Elizabeth ;
French, Dustin D. ;
Bradham, Douglas D. ;
Rubenstein, Laurence Z. .
ANNALS OF EPIDEMIOLOGY, 2007, 17 (07) :514-519
[3]   Continuous loss of bone during chronic immobilization: A monozygotic twin study [J].
Bauman, WA ;
Spungen, AM ;
Wang, J ;
Pierson, RN ;
Schwartz, E .
OSTEOPOROSIS INTERNATIONAL, 1999, 10 (02) :123-127
[4]   Vitamin D deficiency in veterans with chronic spinal cord injury [J].
Bauman, WA ;
Zhong, YG ;
Schwartz, E .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1995, 44 (12) :1612-1616
[5]   COSTS AND HEALTH-EFFECTS OF OSTEOPOROTIC FRACTURES [J].
CHRISCHILLES, E ;
SHIREMAN, T ;
WALLACE, R .
BONE, 1994, 15 (04) :377-386
[6]   Supralesional and sublesional bone mineral density in spinal cord-injured patients [J].
Dauty, M ;
Verbe, BP ;
Maugars, Y ;
Dubois, C ;
Mathe, JF .
BONE, 2000, 27 (02) :305-309
[7]  
Dawson DA, 2003, ALCOHOL RES HEALTH, V27, P18
[8]   The validity of self-reports of alcohol consumption: state of the science and challenges for research [J].
Del Boca, FK ;
Darkes, J .
ADDICTION, 2003, 98 :1-12
[9]   Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass [J].
Ducy, P ;
Amling, M ;
Takeda, S ;
Priemel, M ;
Schilling, AF ;
Beil, FT ;
Shen, JH ;
Vinson, C ;
Rueger, JM ;
Karsenty, G .
CELL, 2000, 100 (02) :197-207
[10]   Assessment of anthropometric, systemic, and lifestyle factors influencing bone status in the legs of spinal cord injured individuals [J].
Eser, P ;
Frotzler, A ;
Zehnder, Y ;
Schiessl, H ;
Denoth, J .
OSTEOPOROSIS INTERNATIONAL, 2005, 16 (01) :26-34