Abnormal bone marrow microenvironment: the "harbor" of acute lymphoblastic leukemia cells

被引：3
作者：
Chen, Zehui [1 ,2 ]
Zheng, Yaxin [1 ]
Yang, Yaling [2 ]
Kang, Junnan [1 ]
You, M. James
Tian, Chen [1 ,2 ]
机构：
[1] Tianjin Med Univ Canc Inst & Hosp, Dept Hematol, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[2] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
来源：
BLOOD SCIENCE | 2021年 / 3卷 / 02期
基金：
中国国家自然科学基金;
关键词：
acute lymphoblastic leukemia; bone marrow microenvironment; osteoblastic niche; vascular niche;
D O I：
10.1097/BS9.0000000000000071
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bone marrow (BM) microenvironment regulates and supports the production of blood cells which are necessary to maintain homeostasis. In analogy to normal hematopoiesis, leukemogenesis is originated from leukemic stem cells (LSCs) which gives rise to more differentiated malignant cells. Leukemia cells occupy BM niches and reconstruct them to support leukemogenesis. The abnormal BM niches are the main sanctuary of LSCs where they can evade chemotherapy-induced death and acquire drug resistance. In this review, we focus on the protective effects of BM niche cells on acute lymphoblastic leukemia cells.
引用
收藏
页码：29 / 34
页数：6
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