The conjugation of rhodamine B enables carrier-free mitochondrial delivery of functional proteins
被引:10
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作者:
Shi, Jiayuan
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Shi, Jiayuan
[1
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Zhao, Dan
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Zhao, Dan
[1
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Li, Xiang
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Li, Xiang
[1
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Ding, Feng
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Ding, Feng
[1
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Tang, Xuemei
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Tang, Xuemei
[1
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Liu, Nian
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Liu, Nian
[2
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Huang, Hua
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Huang, Hua
[1
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Liu, Changlin
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Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R ChinaCent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
Liu, Changlin
[1
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机构:
[1] Cent China Normal Univ, Sch Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China
[2] Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Peoples R China
The development of protein-based therapeutics faces many challenges, for example, carrier-dependence, safety concerns, endocytosis-dependence, and uncertain in vivo therapeutic outcomes. Small molecules are rarely used for intracellular organelle-targeting and disease tissue-specific carrier-independent delivery of therapeutic proteins. Here, we report that rhodamine B, after modification with proteins, is able to guide carrier-free delivery into mitochondria and tissue-dependent distributions of functional proteins through organic cation transporters (OCTs). The enrichment of the modified catalase in the cancer tissue efficiently suppresses xenograft human lung tumor in mice. This carrier-free delivery platform of proteins may emerge as a simple yet powerful approach for cancer treatment.
机构:
Purdue Univ, Dept Ind & Phys Pharm, 575 Stadium Mall Dr, W Lafayette, IN 47907 USAPurdue Univ, Dept Ind & Phys Pharm, 575 Stadium Mall Dr, W Lafayette, IN 47907 USA
Park, Joonyoung
Sun, Bo
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Purdue Univ, Dept Ind & Phys Pharm, 575 Stadium Mall Dr, W Lafayette, IN 47907 USAPurdue Univ, Dept Ind & Phys Pharm, 575 Stadium Mall Dr, W Lafayette, IN 47907 USA
机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Wu, Can
Wang, Chunlu
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Wang, Chunlu
Zheng, Yaoyao
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Zheng, Yaoyao
Zheng, Yaxin
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Zheng, Yaxin
Liu, Ziqi
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Liu, Ziqi
Xu, Keming
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Key Lab Biomed Funct Mat, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
Xu, Keming
Zhong, Wenying
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机构:
China Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Key Lab Biomed Funct Mat, Nanjing 210009, Peoples R China
China Pharmaceut Univ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Chem, Nanjing 210009, Peoples R China
机构:
AstraZeneca, Drug Metab & Pharmacokinet, Res & Early Dev, BioPharmaceut R&D,Resp & Immunol, Gothenburg, SwedenAstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden
Brannstrom, Marie
Ewing, Par
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机构:
AstraZeneca, Drug Metab & Pharmacokinet, Res & Early Dev, BioPharmaceut R&D,Resp & Immunol, Gothenburg, SwedenAstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden
Ewing, Par
Quayle, Michael J.
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机构:
AstraZeneca, Operat, Pharmaceut Technol & Dev, New Modal & Parenteral Dev, Gothenburg, SwedenAstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden