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WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder
被引:6
|作者:
Vallee, Alexandre
[1
]
Lecarpentier, Yves
[2
]
Vallee, Jean-Noel
[3
,4
]
机构:
[1] Foch Hosp, Dept Clin Res & Innovat DRCI, Suresnes, France
[2] Grand Hop IEst Francilien GHEF, Ctr Rech Clin, Meaux, France
[3] Univ Poitiers, Lab Math & Applicat LMA, Poitiers, France
[4] Univ Picardie Jules Verne UPJV, Ctr Hosp Univ CHU Amiens Picardie, Amiens, France
关键词:
circadian rhythms;
glutamatergic pathway;
inflammation;
obsessive-compulsive disorder;
oxidative stress;
WNT/beta-catenin pathway;
NF-KAPPA-B;
CLOCK GENE;
SIGNALING PATHWAY;
DNA-DAMAGE;
BDNF GENE;
WNT;
SLEEP;
BRAIN;
EXPRESSION;
PROTEIN;
D O I:
10.4103/1673-5374.332133
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or compulsions. Obsessive-compulsive disorder etiologies are undefined. However, numerous mechanisms in several localizations are implicated. Some studies showed that both glutamate, inflammatory factors and oxidative stress could have main functions in obsessive-compulsive disorder. Glycogen synthase kinase-3 beta, the major negative controller of the WNT/beta-catenin pathway is upregulated in obsessive-compulsive disorder. In obsessive-compulsive disorder, some studies presented the actions of the different circadian clock genes. WNT/beta-catenin pathway and circadian clock genes appear to be intricate. Thus, this review focuses on the interaction between circadian clock genes and the WNT/beta-catenin pathway in obsessive-compulsive disorder.
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页码:2126 / 2130
页数:5
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