Oxidation of Disulfides to Taurine and Sulfanilic Acid Derivatives

被引：1

作者：

Furtmann, Norbert ^{[1
]}

Gilberg, Erik ^{[1
]}

Spuetz, Nicola ^{[1
]}

Guetschow, Michael ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut, Pharmaceut Chem 1, D-53121 Bonn, Germany

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 17期

关键词：

dipeptides; disulfides; oxidation; sulfanilic acid; sulfonic acids; taurine; SULFATIDE; INHIBITOR; ANALOGS; METABOLITES; PEPTIDES; GROWTH;

D O I：

10.1055/s-0034-1380655

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Taurine (2-aminoethanesulfonic acid) is a representative substructure in biologically active compounds, but can raise difficulties in direct coupling reactions. In this study, the synthesis of taurine-derived sulfonic acids and analogous aromatic sulfonic acids was accomplished by a performic acid promoted oxidation of corresponding symmetrical disulfide precursors. In some of the products, the taurine or sulfanilic acid nitrogen atom is incorporated in a heterocyclic scaffold or part of a peptide bond in dipeptide mimetics.

引用

页码：2609 / 2616

页数：8

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