Involvement of novel PKC isoforms in FFA induced defects in insulin signaling

被引：53

作者：

Dey, D

Basu, D

Roy, SS

Bandyopadhyay, A

Bhattacharya, S ^{[1
]}

机构：

[1] Visva Bharati Univ, Sch Life Sci, Dept Zool, Mol Endocrinol Lab, Santini Ketan 731235, W Bengal, India

[2] Indian Inst Chem Biol, Kolkata 700032, India

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 246卷 / 1-2期

关键词：

novel PKCs; insulin signaling; insulin resistance; free fatty acids; insulin receptor kinase; phosphatidylinositol-dependent kinase 1;

D O I：

10.1016/j.mce.2005.12.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Involvement of novel PKCs (nPKCs) in the negative regulation of insulin-signaling pathway is a current interest of many workers investigating the cause for insulin resistance and type 2 diabetes. Free fatty acids (FFAs) are recently shown to be the major players in inducing insulin resistance in insulin target cells. They are also found to be involved in activating nPKCs associated with the impairment of insulin sensitivity. In this overview, we describe PKC delta, theta and epsilon linked to the FFA induced damage of insulin-signaling molecules. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：60 / 64

页数：5

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