HIV-1 fusion protein exerts complex immunosuppressive effects

被引：18

作者：

Ashkenazi, Avraham ^{[1
]}

Faingold, Omri ^{[1
]}

Shai, Yechiel ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2013年 / 38卷 / 07期

基金：

以色列科学基金会;

关键词：

recognition within membranes; transmembrane domain; T cell receptor complex; T cell inactivation; IMMUNODEFICIENCY-VIRUS TYPE-1; ENVELOPE GLYCOPROTEIN; TRANSMEMBRANE DOMAIN; SYNTHETIC PEPTIDE; T-CELLS; SEQUENCE IDENTITY; DENDRITIC CELLS; MEMBRANE-FUSION; LOOP REGION; GP41;

D O I：

10.1016/j.tibs.2013.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the routes by which HIV-1 is able to escape the immune response is by immunosuppression. The gp41 fusion protein of the HIV-1 envelope mediates virus entry by membrane fusion and also functions as an inhibitor of T cell activation. Here, we review the recent studies suggesting that some of the gp41 immunosuppressive processes are initiated by novel motifs, located within the hydrophobic regions of the protein. This indicates that the immunosuppressive process mediated by gp41 is much more complex than initially thought. Additionally, we propose a model illustrating the interactions and interferences of these regions with the T cell receptor complex.

引用

页码：345 / 349

页数：5

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