Time Course of Islet Loss after Intraportal Transplantation

被引：7

作者：

Pawelec, Krystian ^{[1
]}

Juszczak, Maciej Tadeusz ^{[1
]}

Kumar, Anila ^{[1
]}

Powis, Steve Hugh ^{[1
]}

Press, Martin ^{[1
]}

机构：

[1] Royal Free & Univ Coll Med Sch, Univ Coll London, Dept Endocrinol & Diabet, Royal Free Hampstead NHS Trust & Ctr Nephrol, London NW3 2PE, England

来源：

Immunology of Diabetes V: From Bench to Bedside | 2008年 / 1150卷

关键词：

pancreatic islet transplantation; islet survival; diabetes; selective intraportal transplantation; islet:bead ratio;

D O I：

10.1196/annals.1447.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A high percentage of islets fail to survive intraportal transplantation, but the absolute amount and time course of this loss are uncertain. We have devised a technique to directly quantitate the number of surviving islets using simultaneous selective transplantation of islets and inert beads into the posterior lobes of the liver. Islet:bead ratio did not change significantly within the first 2 hours, but fell progressively thereafter, giving calculated islet survival rates of 89, 43, and 66% at days 1, 7 and 28, respectively. This technique provides a baseline from which to develop strategies to improve the survival of intraportally transplanted islets.

引用

收藏

页码：230 / 233

页数：4

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