Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing

被引：13

作者：

Rice, William L. ^{[1
]}

Hou, Steven ^{[1
]}

Kumar, Anand T. N. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Athinoula A Martinos Ctr Biomed Imaging,Dept Radi, Charlestown, MA 02129 USA

来源：

OPTICS LETTERS | 2013年 / 38卷 / 12期

基金：

美国国家卫生研究院;

关键词：

TOMOGRAPHY; DOMAIN; CONTRAST; SYSTEM;

D O I：

10.1364/OL.38.002038

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable to achieve this separation, indicating the unique advantage of a decay-amplitude-based approach for tomographic lifetime multiplexing with time domain data. (c) 2013 Optical Society of America

引用

页码：2038 / 2040

页数：3

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