Organizing the genome with H2A histone variants

被引：28

作者：

Millar, Catherine B. ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

BIOCHEMICAL JOURNAL | 2013年 / 449卷

基金：

英国惠康基金;

关键词：

chromatin; H2A.B; H2A.X; H2A.Z; histone variant; mH2A; INACTIVE X-CHROMOSOME; CHROMATIN REMODELING COMPLEX; NUCLEOSOME CORE PARTICLE; MESSENGER-RNAS; POSTTRANSLATIONAL MODIFICATIONS; CRYSTAL-STRUCTURE; POLYCOMB COMPLEX; VERTEBRATE H2A.Z; H2A-H2B DIMERS; TERMINAL TAIL;

D O I：

10.1042/BJ20121646

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin acts as an organizer and indexer of genomic DNA and is a highly dynamic and regulated structure with properties directly related to its constituent parts. Histone variants are abundant components of chromatin that replace canonical histones in a subset of nucleosomes, thereby altering nucleosomal characteristics. The present review focuses on the H2A variant histones, summarizing current knowledge of how H2A variants can introduce chemical and functional heterogeneity into chromatin, the positions that nucleosomes containing H2A variants occupy in eukaryotic genomes, and the regulation of these localization patterns.

引用

页码：567 / 579

页数：13

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