Organizing the genome with H2A histone variants

被引：28
作者：
Millar, Catherine B. [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
BIOCHEMICAL JOURNAL | 2013年 / 449卷
基金：
英国惠康基金;
关键词：
chromatin; H2A.B; H2A.X; H2A.Z; histone variant; mH2A; INACTIVE X-CHROMOSOME; CHROMATIN REMODELING COMPLEX; NUCLEOSOME CORE PARTICLE; MESSENGER-RNAS; POSTTRANSLATIONAL MODIFICATIONS; CRYSTAL-STRUCTURE; POLYCOMB COMPLEX; VERTEBRATE H2A.Z; H2A-H2B DIMERS; TERMINAL TAIL;
D O I：
10.1042/BJ20121646
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromatin acts as an organizer and indexer of genomic DNA and is a highly dynamic and regulated structure with properties directly related to its constituent parts. Histone variants are abundant components of chromatin that replace canonical histones in a subset of nucleosomes, thereby altering nucleosomal characteristics. The present review focuses on the H2A variant histones, summarizing current knowledge of how H2A variants can introduce chemical and functional heterogeneity into chromatin, the positions that nucleosomes containing H2A variants occupy in eukaryotic genomes, and the regulation of these localization patterns.
引用
收藏
页码：567 / 579
页数：13
相关论文
共 167 条
[1]   H2A.Z is required for global chromatin integrity and for recruitment of RNA polymerase II under specific conditions [J].
Adam, M ;
Robert, F ;
Larochelle, M ;
Gaudreau, L .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (18) :6270-6279
[2]   Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome [J].
Albert, Istvan ;
Mavrich, Travis N. ;
Tomsho, Lynn P. ;
Qi, Ji ;
Zanton, Sara J. ;
Schuster, Stephan C. ;
Pugh, B. Franklin .
NATURE, 2007, 446 (7135) :572-576
[3]   NuA4-dependent Acetylation of Nucleosomal Histones H4 and H2A Directly Stimulates Incorporation of H2A.Z by the SWR1 Complex [J].
Altaf, Mohammed ;
Auger, Andreanne ;
Monnet-Saksouk, Julie ;
Brodeur, Joelle ;
Piquet, Sandra ;
Cramet, Myriam ;
Bouchard, Nathalie ;
Lacoste, Nicolas ;
Utley, Rhea T. ;
Gaudreau, Luc ;
Cote, Jacques .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (21) :15966-15977
[4]   Nucleolin is a histone chaperone with FACT-like activity and assists remodeling of nucleosomes [J].
Angelov, Dimitar ;
Bondarenko, Vladimir A. ;
Almagro, Sebastien ;
Menoni, Herve ;
Mongelard, Fabien ;
Hans, Fabienne ;
Mietton, Flore ;
Studitsky, Vasily M. ;
Hamiche, Ali ;
Dimitrov, Stefan ;
Bouvet, Philippe .
EMBO JOURNAL, 2006, 25 (08) :1669-1679
[5]   The many tales of a tail:: Carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin function [J].
Ausió, J ;
Abbott, DW .
BIOCHEMISTRY, 2002, 41 (19) :5945-5949
[6]   Histone Variants in Metazoan Development [J].
Banaszynski, Laura A. ;
Allis, C. David ;
Lewis, Peter W. .
DEVELOPMENTAL CELL, 2010, 19 (05) :662-674
[7]   Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA [J].
Bao, YH ;
Konesky, K ;
Park, YJ ;
Rosu, S ;
Dyer, PN ;
Rangasamy, D ;
Tremethick, DJ ;
Laybourn, PJ ;
Luger, K .
EMBO JOURNAL, 2004, 23 (16) :3314-3324
[8]   High-resolution profiling of histone methylations in the human genome [J].
Barski, Artern ;
Cuddapah, Suresh ;
Cui, Kairong ;
Roh, Tae-Young ;
Schones, Dustin E. ;
Wang, Zhibin ;
Wei, Gang ;
Chepelev, Iouri ;
Zhao, Keji .
CELL, 2007, 129 (04) :823-837
[9]   A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis [J].
Bernstein, Emily ;
Muratore-Schroeder, Tara L. ;
Diaz, Robert L. ;
Chow, Jennifer C. ;
Changolkar, Lakshmi N. ;
Shabanowitz, Jeffrey ;
Heard, Edith ;
Pehrson, John R. ;
Hunt, Donald F. ;
Allis, C. David .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1533-1538
[10]   Histone H2A variants in nucleosomes and chromatin: more or less stable? [J].
Boenisch, Clemens ;
Hake, Sandra B. .
NUCLEIC ACIDS RESEARCH, 2012, 40 (21) :10719-10741
12345678910