Biocatalytic synthesis of hydroxylated natural products using aldolases and related enzymes

被引：115
作者：
Fessner, WD
Helaine, V
机构：
[1] Tech Univ Darmstadt, Dept Organ Chem, D-64287 Darmstadt, Germany
[2] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, F-63177 Aubiere, France
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0958-1669(01)00265-8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthetic building blocks bearing hydroxylated chiral centers are important targets for biocatalysis. Many C-C bond forming enzymes have recently been investigated for new applications and new strategies towards the synthesis of natural products and related oxygenated compounds. Several old catalysts have been studied to increase our functional knowledge of natural aldolase-type enzymes, and new mutated catalysts or catalytic antibodies have been tested for their synthetic utility.
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页码：574 / 586
页数：13
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