Antiproliferative Triterpenes from Melaleuca ericifolia

被引：29

作者：

Bar, Fatma M. Abdel ^{[1
,2
]}

Zaghloul, Ahmed M. ^{[2
]}

Bachawal, Sunitha V. ^{[1
]}

Sylvester, Paul W. ^{[1
]}

Ahmad, Kadria F. ^{[2
]}

El Sayed, Khalid A. ^{[1
]}

机构：

[1] Univ Louisiana Monroe, Coll Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 71209 USA

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 10期

关键词：

D O I：

10.1021/np800360a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new 28-norlupane triterpenes, 28-norlup-20(29)-en-3 beta-hydroxy-17 beta-hydroperoxide (1). 28-norlup-20(29)-en-3 beta-hydroxy-17 alpha-hydroperoxide (2), and 20S-17 beta,29-epoxy-28-norlupan-3 beta-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The Structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.

引用

页码：1787 / 1790

页数：4

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