A low-cost open-source SNP genotyping platform for association mapping applications

被引：22

作者：

Macdonald, SJ ^{[1
]}

Pastinen, T

Genissel, A

Cornforth, TW

Long, AD

机构：

[1] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA

[2] McGill Univ, Montreal, PQ H3A 1A4, Canada

[3] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada

[4] Univ Calif Davis, Sect Evolut & Ecol, Davis, CA 95616 USA

[5] 1254 Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 12期

关键词：

D O I：

10.1186/gb-2005-6-12-r105

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Association mapping aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of individuals. Few technologies, however, provide inexpensive high-throughput genotyping. Here, we present an efficient approach developed specifically for genotyping large fixed panels of diploid individuals. The cost-effective, open-source nature of our methodology may make it particularly attractive to those working in nonmodel systems.

引用

页数：11

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