Sodium in the microenvironment regulates immune responses and tissue homeostasis

被引:113
作者
Mueller, Dominik N. [1 ,2 ,3 ]
Wilck, Nicola [1 ,2 ,4 ]
Haase, Stefanie [5 ]
Kleinewietfeld, Markus [6 ]
Linker, Ralf A. [5 ]
机构
[1] Joint Cooperat Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany
[2] Charite Univ Med Berlin, Berlin, Germany
[3] Helmholtz Assoc, Max Delbruck Ctr Mol Med, Berlin, Germany
[4] Charite Univ Med Berlin, Div Nephrol & Internal Intens Care Med, Berlin, Germany
[5] Univ Regensburg, Dept Neurol, Regensburg, Germany
[6] Hasselt Univ, VIB Ctr Inflammat Res IRC, VIB Lab Translat Immunomodulat, Diepenbeek, Belgium
基金
欧洲研究理事会;
关键词
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ANTIBIOTIC-INDUCED CHANGES; ARYL-HYDROCARBON RECEPTOR; II-INDUCED HYPERTENSION; GUT MICROBIOTA; INTERSTITIAL FLUID; BLOOD-PRESSURE; INTESTINAL MICROBIOTA; URINARY SODIUM; NA+ STORAGE;
D O I
10.1038/s41577-018-0113-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During tissue inflammation, immune cells infiltrate the interstitial space of target organs, where they sense and adapt to local environmental stimuli. Such stimuli include not only pathogens but also local factors such as the levels of oxygenation, nutrients and electrolytes. An important electrolyte in this regard is sodium (Na+). Recent in vivo findings have shown a role of Na+ storage in the skin for electrolyte homeostasis. Thereby, Na+ intake may influence the activation status of the immune system through direct effects on T helper cell subsets and innate immune cells in tissues such as the skin and other target organs. Furthermore, high Na+ intake has been shown to alter the composition of the intestinal microbiota, with indirect effects on immune cells. The results suggest regulatory roles for Na+ in cardiovascular disease, inflammation, infection and autoimmunity.
引用
收藏
页码:243 / 254
页数:12
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