Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

被引：9

作者：

Cattopadhyay, Kalicharan ^{[1
]}

Recio, Antonio, III ^{[1
]}

Tunge, Jon A. ^{[1
]}

机构：

[1] Haldia Inst Technol, Haldia, W Bengal, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 34期

基金：

美国国家卫生研究院;

关键词：

REGIOSELECTIVE ALPHA-ALKYLATION; ASYMMETRIC ALLYLIC ALKYLATION; BIOLOGICAL EVALUATION; CARBONYL-COMPOUNDS; TRANSITION-METAL; PRIMARY ALCOHOLS; DECARBOXYLATIVE BENZYLATION; NUCLEOPHILIC-SUBSTITUTION; NICKEL NANOPARTICLES; BENZYLIC CARBONATES;

D O I：

10.1039/c2ob25962a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the palladium-catalyzed, pyrrolidine-mediated alpha-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd-pi-benzyl complex generated from (coumarinyl)methyl acetates.

引用

页码：6826 / 6829

页数：4

共 92 条

[1] Direct Regiospecific and Highly Enantioselective Intermolecular a-Allylic Alkylation of Aldehydes by a Combination of Transition-Metal and Chiral Amine Catalysts [J].