Successful steroid-sparing treatment of renal limited sarcoidosis with mycophenolate mofetil

被引：52
作者：
Moudgil, A
Przygodzki, RM
Kher, KK
机构：
[1] Childrens Natl Med Ctr, Div Nephrol, Washington, DC 20010 USA
[2] Childrens Natl Med Ctr, Div Pathol, Washington, DC 20010 USA
来源：
PEDIATRIC NEPHROLOGY | 2006年 / 21卷 / 02期
关键词：
sarcoidosis; renal failure; interstitial nephritis; mycophenolate mofetil; granulomas;
D O I：
10.1007/s00467-005-2086-3
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Sarcoidosis is a multi-system disorder characterized by non-caseating epithelioid granulomas in multiple organs. The disease usually presents in young adults and is uncommon in children. Renal involvement can usually occur due to granulomatous interstitial nephritis, but renal failure is uncommon. Corticosteroids are the mainstay of therapy. We present the report of a child with severe renal failure secondary to renal limited sarcoidosis who was successfully treated with corticosteroid induction therapy. Because of the severe side effects of corticosteroids, mycophenolate mofetil was added and corticosteroids were tapered off. The child has been in sustained remission for over a year with mycophenolate mofetil monotherapy.
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收藏
页码：281 / 285
页数：5
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