Influence of striatal dopamine transporter availability on the response to methylphenidate in adult patients with ADHD

被引：68
作者：
Krause, J
la Fougere, C
Krause, KH
Ackenheil, M
Dresel, SH
机构：
[1] Outpatient Clin Psychiat & Psychotherapy, D-85521 Ottobrunn, Germany
[2] Univ Munich, Dept Nucl Med, Munich, Germany
[3] Univ Munich, Freidrich Baur Inst, Munich, Germany
[4] Univ Munich, Dept Neurochem, Munich, Germany
来源：
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2005年 / 255卷 / 06期
关键词：
attention deficit hyperactivity disorder (ADHD); brain imaging techniques; dopamine transporter; methylphenidate; TRODAT-1; SPECT;
D O I：
10.1007/s00406-005-0602-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this study, we investigated whether availability of striatal dopamine transporter (DAT) may have an influence on the response of adult patients with attention deficit hyperactivity disorder (ADHD) on methylphenidate (MPH). In 18 non-smoking and non-medicated adult patients with ADHD, availability of DAT was measured with [Tc-99m] TRODAT-1 SPECT. Then, the patients received methylphenidate (MPH), individually titrated up to 60 mg per day. Ten weeks later, clinical improvement was rated by Clinical Global Impressions scale. In all, 6 patients were classified as non-responders, and 12 responded to MPH. From the non-responders, 5 presented with a DAT availability below that of normal controls of the same age, whereas in the group of responders all patients had elevated DAT availability. There was a significant negative correlation between values for global clinical improvement and striatal DAT availability. In conclusion, ADHD patients with low DAT availability seem not to respond to therapy with MPH.
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收藏
页码：428 / 431
页数：4
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