Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights

被引：30

作者：

Kriaa, Aicha ^{[1
]}

Bourgin, Melanie ^{[1
]}

Mkaouar, Hela ^{[1
]}

Jablaoui, Amin ^{[1
]}

Akermi, Nizar ^{[1
]}

Soussou, Souha ^{[1
]}

Maguin, Emmanuelle ^{[1
]}

Rhimi, Moez ^{[1
]}

机构：

[1] Univ Paris Saclay, INRA, Microbiota Interact Human & Anim Team MIHA, AgroParisTech,UMR Micalis 1319, F-78350 Jouy En Josas, France

来源：

CATALYSTS | 2019年 / 9卷 / 02期

关键词：

cholesterol; coprostanol; reduction reaction; bacteria; metabolic pathways; EUBACTERIUM-COPROSTANOLIGENES; REDUCING BACTERIUM; BILE-ACIDS; GERM-FREE; OXIDASE; CONVERSION; TRANSFORMATION; ABSORPTION; MECHANISM; METABOLISM;

D O I：

10.3390/catal9020167

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Three microbial pathways of coprostanol production were described based on the analysis of reaction intermediates. However, these metabolic pathways and their associated genes remain poorly studied. In this review, we shed light on the microbial metabolic pathways related to coprostanol synthesis. Moreover, we highlight current strategies and future directions to better characterize these microbial enzymes and pathways.

引用

页数：10

共 76 条

[1] An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection [J].