Iridium-Catalyzed Allylic Alkylation Reaction with N-Aryl Phosphoramidite Ligands: Scope and Mechanistic Studies

被引：167

作者：

Liu, Wen-Bo ^{[1
]}

Zheng, Chao ^{[1
]}

Zhuo, Chun-Xiang ^{[1
]}

Dai, Li-Xin ^{[1
]}

You, Shu-Li ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; COMPLEXES-RESTING STATES; ASYMMETRIC HYDROGENATION; KINETIC RESOLUTION; ENANTIOSELECTIVE HYDROGENATION; PHOSPHORUS AMIDITES; DENSITY FUNCTIONALS; ASTERISK-IR; SUBSTITUTION; AMINATION;

D O I：

10.1021/ja210923k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of N-aryl phosphoramidite ligands has been synthesized and applied to iridium-catalyzed allylic alkylation reactions, offering high regio- and enantioselectivities for a wide variety of substrates. These ligands feature the synthetic convenience and good tolerance of the ortho-substituted cinnamyl carbonates. Mechanistic studies, including DFT calculations and X-ray crystallographic analyses of the (pi-allyl)-Ir complexes, reveal that the active iridacycle is formed via C(sp(2))-H bond activation.

引用

页码：4812 / 4821

页数：10

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