Frontostriatal Connectivity in Children during Working Memory and the Effects of Prenatal Methamphetamine, Alcohol, and Polydrug Exposure

被引:34
作者
Roussotte, Florence F. [2 ]
Rudie, Jeffrey D. [4 ]
Smith, Lynne [5 ]
O'Connor, Mary J. [4 ]
Bookheimer, Susan Y. [4 ]
Narr, Katherine L. [3 ]
Sowell, Elizabeth R. [1 ,2 ]
机构
[1] Univ So Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dev Cognit Neuroimaging Lab, Los Angeles, CA 90027 USA
[2] Univ So Calif, Dept Pediat, Los Angeles, CA 90027 USA
[3] Univ Calif Los Angeles, Dept Neurol, Lab NeuroImaging, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA
[5] Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA
基金
美国国家卫生研究院;
关键词
Children; Developing brain; Drugs of abuse; Magnetic resonance imaging; Neurotoxicity; Prenatal alcohol exposure; Prenatal methamphetamine exposure; Prenatal polydrug exposure; Methamphetamine; Teratogens; Functional connectivity; Polydrug exposure; RAT CEREBRAL-CORTEX; BASAL-GANGLIA; FETAL ALCOHOL; MAGNETIC-RESONANCE; ETHANOL EXPOSURE; IN-UTERO; CORTICOSTRIATAL CIRCUITS; FUNCTIONAL CONNECTIVITY; INTRAUTERINE GROWTH; HUNTINGTONS-DISEASE;
D O I
10.1159/000336242
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and polydrug exposure. Because the putamen is part of the corticostriatal motor loop whereas the caudate is involved in the executive loop, we hypothesized that a loss of segregation between distinct corticostriatal networks may occur in these participants. The current study was designed to test this hypothesis using functional connectivity MRI. We examined 50 children ranging in age from 7 to 15, including 19 with prenatal methamphetamine exposure (15 of whom had concomitant prenatal alcohol exposure), 13 with prenatal exposure to alcohol but not methamphetamine, and 18 unexposed controls. We measured the coupling between blood oxygenation level dependent (BOLD) fluctuations during a working-memory task in four striatal seed regions and those in the rest of the brain. We found that the putamen seeds showed increased connectivity with frontal brain regions involved in executive functions while the caudate seeds showed decreased connectivity with some of these regions in both groups of exposed subjects compared to controls. These findings suggest that localized brain abnormalities resulting from prenatal exposure to alcohol and/or methamphetamine lead to a partial rewiring of corticostriatal networks. These results represent important progress in the field, and could have substantial clinical significance in helping devise more targeted treatments and remediation strategies designed to better serve the needs of this population. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码:43 / 57
页数:15
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