Mast cells as regulators of adaptive immunity to tumours

被引：68

作者：

Wasiuk, A. ^{[1
]}

de Vries, V. C. ^{[1
]}

Hartmann, K. ^{[2
]}

Roers, A. ^{[2
]}

Noelle, R. J. ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Univ Cologne, Dept Dermatol, D-5000 Cologne, Germany

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2009年 / 155卷 / 02期

关键词：

acquired immunity; immunosuppression; mast cells; tumour; PROSTAGLANDIN D-2; DENDRITIC CELLS; T-CELLS; DIFFERENTIAL RELEASE; HISTAMINE-RECEPTORS; LANGERHANS CELLS; ACTIVATION; SEROTONIN; MIGRATION; MICE;

D O I：

10.1111/j.1365-2249.2008.03840.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The observation that mast cells accumulate at the periphery of growing tumours is now well documented, and the loss of mast cells correlates with reduced tumour growth. The role of mast cells as innate regulators of both inflammatory and immunosuppressive responses slowly becomes clear as novel tools become available. This review will address the role of mast cells in tumours and how they can interact with the local immune environment to mediate immune suppression contributing to tumour escape.

引用

页码：140 / 146

页数：7

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