Smoking as a Risk Factor for Complications in Chronic Pancreatitis

被引:44
作者
Luaces-Regueira, Maria [1 ]
Iglesias-Garcia, Julio [1 ,2 ]
Lindkvist, Bjorn [1 ,3 ]
Castineira-Alvarino, Margarita [1 ]
Nieto-Garcia, Laura [1 ]
Larino-Noia, Jose [1 ,2 ]
Enrique Dominguez-Munoz, J. [1 ,2 ]
机构
[1] Univ Hosp Santiago de Compostela, Fdn Res Digest Dis, Santiago De Compostela 15706, Spain
[2] Univ Hosp Santiago de Compostela, Dept Gastroenterol, Santiago De Compostela 15706, Spain
[3] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden
关键词
pancreatic exocrine insufficiency; pancreatic disease; breath test; alcohol; chronic pancreatitis; IDIOPATHIC CHRONIC-PANCREATITIS; CIGARETTE-SMOKING; ENDOSCOPIC ULTRASONOGRAPHY; EXOCRINE INSUFFICIENCY; NICOTINE; ALCOHOL; RATS; DIAGNOSIS; THERAPY; TOBACCO;
D O I
10.1097/01.mpa.0000437324.52598.ee
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives Several recent studies have demonstrated the association between smoking and chronic pancreatitis (CP). However, less is known about the role of smoking in the development of CP-related complications. Our aim was to investigate the impact of smoking and alcohol consumption on age of onset and complications at CP diagnosis. Methods A cross-sectional case-case study was performed within a prospectively collected cohort of patients with CP. Alcohol consumption and smoking habits were assessed using a standardized questionnaire. Morphologic severity was defined based on endoscopic ultrasound criteria for CP and classified as mild (3-4 criteria), moderate (5-6 criteria), and severe (>= 7 criteria or calcifications). Pancreatic exocrine insufficiency (PEI) was diagnosed using the C-13-mixed triglyceride breath test. Odds ratios (OR) with 95% confidence intervals (CI) for CP-related complications were calculated using a case-case design. Results A total of 241 patients were included. Smoking was associated with PEI (OR [95% CI], 2.4 [1.17-5.16]), calcifications (OR [95% CI], 2.33 [1.10-4.95]), and severe morphologic changes (OR [95% CI], 3.41 [1.31-8.85]) but not with pseudocysts or diabetes. Neither smoking nor alcohol consumption was associated with age of onset. Conclusions Tobacco, but not alcohol, is associated with PEI, calcifications, and severe morphologic (>= 7 criteria or calcifications) CP at diagnosis. Smoking cessation should be encouraged in patients with CP.
引用
收藏
页码:275 / 280
页数:6
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