Regulation of the APC and the exit from mitosis

被引：303
作者：
Morgan, DO [1 ]
机构：
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
来源：
NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期
关键词：
D O I：
10.1038/10039
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin-dependent proteloysis of key regulatory proteins. An intricate regulatory network governs Ape activity and helps to ensure that late mitotic events are properly timed and coordinated.
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页码：E47 / E53
页数：7
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