Regulation of the APC and the exit from mitosis

被引：303
作者：
Morgan, DO [1 ]
机构：
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
来源：
NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期
关键词：
D O I：
10.1038/10039
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin-dependent proteloysis of key regulatory proteins. An intricate regulatory network governs Ape activity and helps to ensure that late mitotic events are properly timed and coordinated.
引用
收藏
页码：E47 / E53
页数：7
相关论文
共 103 条
[1]  
ALEXANDRU G, IN PRESS EMBO J
[2]   Robustness in bacterial chemotaxis [J].
Alon, U ;
Surette, MG ;
Barkai, N ;
Leibler, S .
NATURE, 1999, 397 (6715) :168-171
[3]   Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast [J].
Amon, A .
EMBO JOURNAL, 1997, 16 (10) :2693-2702
[4]   Robustness in simple biochemical networks [J].
Barkai, N ;
Leibler, S .
NATURE, 1997, 387 (6636) :913-917
[5]   Drosophila Polo kinase is required for cytokinesis [J].
Carmena, M ;
Riparbelli, MG ;
Minestrini, G ;
Tavares, AM ;
Adams, R ;
Callaini, G ;
Glover, DM .
JOURNAL OF CELL BIOLOGY, 1998, 143 (03) :659-671
[6]   The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae [J].
Charles, JF ;
Jespersen, SL ;
Tinker-Kulberg, RL ;
Hwang, L ;
Szidon, A ;
Morgan, DO .
CURRENT BIOLOGY, 1998, 8 (09) :497-507
[7]   Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores [J].
Chen, RH ;
Waters, JC ;
Salmon, ED ;
Murray, AW .
SCIENCE, 1996, 274 (5285) :242-246
[8]   An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast [J].
Ciosk, R ;
Zachariae, W ;
Michaelis, C ;
Shevchenko, A ;
Mann, M ;
Nasmyth, K .
CELL, 1998, 93 (06) :1067-1076
[9]   Temporal and spatial control of cyclin B1 destruction in metaphase [J].
Clute, P ;
Pines, J .
NATURE CELL BIOLOGY, 1999, 1 (02) :82-87
[10]   The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway [J].
Cohen-Fix, O ;
Koshland, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14361-14366
12345678910