Hydrogenative Dearomatization of Pyridine and an Asymmetric Aza-Friedel-Crafts Alkylation Sequence

被引：91
作者：
Wang, Shuo-Guo [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 08期
关键词：
asymmetric catalysis; heterocycles; organocatalysis; reduction; synthetic methods; ORGANOCATALYTIC TRANSFER HYDROGENATION; PHOSPHORIC-ACIDS; HANTZSCH ESTERS; AMPHIBIAN SKIN; ENANTIOSELECTIVE ADDITION; ARTHROPOD ALKALOIDS; DERIVATIVES; QUINOLINES; INDOLES; PIPERIDINES;
D O I：
10.1002/anie.201309876
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza-Friedel-Crafts reaction in good to excellent yields and enantioselectivity.
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收藏
页码：2194 / 2197
页数：4
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