Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine

被引：38
作者：
Ali, Meer Tarique [1 ]
Fule, Ritesh [1 ]
Sav, Ajay [1 ]
Amin, Purnima [1 ]
机构：
[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India
来源：
AAPS PHARMSCITECH | 2013年 / 14卷 / 03期
关键词：
carbamazepine; dissolution; solubility enhancement; ORAL DELIVERY; DISSOLUTION; RELEASE; BIOAVAILABILITY; MODULATION; POLYMERS; SBA-15; DRUGS;
D O I：
10.1208/s12249-013-9985-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.
引用
收藏
页码：919 / 926
页数：8
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