Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine

被引：41

作者：

Ali, Meer Tarique ^{[1
]}

Fule, Ritesh ^{[1
]}

Sav, Ajay ^{[1
]}

Amin, Purnima ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

来源：

AAPS PHARMSCITECH | 2013年 / 14卷 / 03期

关键词：

carbamazepine; dissolution; solubility enhancement; ORAL DELIVERY; DISSOLUTION; RELEASE; BIOAVAILABILITY; MODULATION; POLYMERS; SBA-15; DRUGS;

D O I：

10.1208/s12249-013-9985-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.

引用

页码：919 / 926

页数：8

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