The bile salt export pump (BSEP) in health and disease

被引：151

作者：

Kubitz, Ralf ^{[1
]}

Droege, Carola ^{[1
]}

Stindt, Jan ^{[1
]}

Weissenberger, Katrin ^{[1
]}

Haeussinger, Dieter ^{[1
]}

机构：

[1] Univ Dusseldorf, Fac Med, Dept Gastroenterol Hepatol & Infect Dis, Univ Hosp, D-40225 Dusseldorf, Germany

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2012年 / 36卷 / 06期

关键词：

FAMILIAL INTRAHEPATIC CHOLESTASIS; PROTEIN-KINASE-C; FARNESOID-X-RECEPTOR; MULTIDRUG-RESISTANCE PROTEIN-2; INDUCED LIVER-INJURY; ESTRADIOL 17-BETA-D-GLUCURONIDE-INDUCED CHOLESTASIS; TAUROURSODEOXYCHOLIC ACID INSERTS; EXTRACORPOREAL ALBUMIN DIALYSIS; EXTERNAL BILIARY DIVERSION; ORGANIC ANION TRANSPORTERS;

D O I：

10.1016/j.clinre.2012.06.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from hepatocytes into bile in humans. Mutations of BSEP are associated with cholestatic liver diseases of varying severity including progressive familial intrahepatic cholestasis type 2 (PFIC-2), benign recurrent intrahepatic cholestasis type 2 (BRIC-2) and genetic polymorphisms are linked to intrahepatic cholestasis of pregnancy (ICP) and drug-induced liver injury (DILI). Detailed analysis of these diseases has considerably increased our knowledge about physiology and pathophysiology of bile secretion in humans. This review focuses on expression, localization, and function, short- and long-term regulation of BSEP as well as diseases association and treatment options for BSEP-associated diseases. (c) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：536 / 553

页数：18

共 229 条

[11] Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy [J].

Bernhardt, Gerwin A. ;

Zollner, Gernot ;

Cerwenka, Herwig ;

Kornprat, Peter ;

Fickert, Peter ;

Bacher, Heinz ;

Werkgartner, Georg ;

Mueller, Gabriele ;

Zatloukal, Kurt ;

Mischinger, Hans-Joerg ;

Trauner, Michael .

LIVER INTERNATIONAL, 2012, 32 (01) :119-127

[12] Bile acids as endogenous etiologic agents in gastrointestinal cancer [J].

Bernstein, Harris ;

Bernstein, Carol ;

Payne, Claire M. ;

Dvorak, Katerina .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (27) :3329-3340

[13] Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes [J].

Beuers, U ;

Throckmorton, DC ;

Anderson, MS ;

Isales, CM ;

Thasler, W ;

KullakUblick, GA ;

Sauter, G ;

Koebe, HG ;

Paumgartner, G ;

Boyer, JL .

GASTROENTEROLOGY, 1996, 110 (05) :1553-1563

[14] Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver [J].

Beuers, U ;

Bilzer, M ;

Chittattu, A ;

Kullak-Ublick, GA ;

Keppler, D ;

Paumgartner, G ;

Dombrowski, F .

HEPATOLOGY, 2001, 33 (05) :1206-1216

[15] Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes [J].

Beuers, U ;

Probst, I ;

Soroka, C ;

Boyer, JL ;

Kullak-Ublick, GA ;

Paumgartner, G .

HEPATOLOGY, 1999, 29 (02) :477-482

[16] EASL Clinical Practice Guidelines: Management of cholestatic liver diseases [J].

Beuers, Ulrich ;

Boberg, Kirsten M. ;

Chapman, Roger W. ;

Chazouilleres, Olivier ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lammert, Frank ;

Pares, Albert ;

Trauner, Michael .

JOURNAL OF HEPATOLOGY, 2009, 51 (02) :237-267

[17] Phosphoinositide 3-Kinase/Protein Kinase B Signaling Pathway Is Involved in Estradiol 17β-D-Glucuronide-Induced Cholestasis: Complementarity with Classical Protein Kinase C [J].

Boaglio, Andrea C. ;

Zucchetti, Andres E. ;

Sanchez Pozzi, Enrique J. ;

Pellegrino, Jose M. ;

Elena Ochoa, Justina ;

Mottino, Aldo D. ;

Vore, Mary ;

Crocenzi, Fernando A. ;

Roma, Marcelo G. .

HEPATOLOGY, 2010, 52 (04) :1465-1476

[18] Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms [J].

Bolder, U ;

Jeschke, MG ;

Landmann, L ;

Wolf, F ;

de Sousa, C ;

Schlitt, HJ ;

Przkora, R .

CELL STRESS & CHAPERONES, 2006, 11 (01) :89-100

[19] Byler-like familial cholestasis in an extended kindred [J].

Bourke, B ;

Goggin, N ;

Walsh, D ;

Kennedy, S ;

Setchell, KDR ;

Drumm, B .

ARCHIVES OF DISEASE IN CHILDHOOD, 1996, 75 (03) :223-227

[20] BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS - A REPORT OF 26 CASES [J].

BRENARD, R ;

GEUBEL, AP ;

BENHAMOU, JP .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 1989, 11 (05) :546-551

← 1 2 3 4 5 6 7 8 9 10 →