DIAGNOSTIC UTILITY OF ADENOSINE DEAMINASE IN SERUM AND BRONCHOALVEOLAR LAVAGE FLUID FOR SCREENING LUNG CANCER IN WESTERN IRAN

被引：9
|
作者：
Nikkhoo, Bahram [1 ]
Sigari, Naseh [2 ]
Ghaderi, Bayazid [2 ]
Afkhamzadeh, Abdolrahim [3 ]
Azadi, Namam-Ali [4 ]
Mohsenpour, Behzad [5 ]
Fathi, Fardin [6 ]
Abdi, Mohammad [1 ]
机构：
[1] Kurdistan Univ Med Sci, Fac Para Med, Dept Pathol & Clin Lab Sci, Sanandaj, Iran
[2] Kurdistan Univ Med Sci, Dept Internal Med, Fac Med, Sanandaj, Iran
[3] Kurdistan Univ Med Sci, Dept Community Med, Kurdistan Univ Res Ctr Gastroenterol & Liver Dis, Sanandaj, Iran
[4] Kurdistan Univ Med Sci, Fac Med, Dept Epidemiol & Biostat, Sanandaj, Iran
[5] Kurdistan Univ Med Sci, Fac Med, Dept Infect Dis, Sanandaj, Iran
[6] Kurdistan Univ Med Sci, Fac Med, Ctr Cellular & Mol Res, Sanandaj, Iran
来源：
JOURNAL OF MEDICAL BIOCHEMISTRY | 2013年 / 32卷 / 02期
关键词：
adenosine deaminase; lung cancer; serum; bronchoalveolar lavage; diagnostic value; ENZYME-ACTIVITIES; SPUTUM; ADA1; TUBERCULOSIS; ISOENZYMES;
D O I：
10.2478/jomb-2013-0011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: This study aimed to determine adenosine deaminase (ADA) activity as a possible screening tool in lung cancer patients. Methods: Blood samples were collected from 30 subjects with positive pathological tests and 62 patients with negative pathological tests as a control group. The enzymatic activity of total ADA and its isoenzymes was determined. Results: tADA and ADA2 isoenzyme activity was significantly higher in cancerous patients compared to benign controls in serum and BAL fluid. Using a cut-off level of respectively 35.22 U/L and 31.80 U/L for BAL total ADA and ADA2, sensitivity and specificity were 100% and 81% for total ADA and 95% and 98% for ADA2. Conclusions: Adenosine deaminase may play important roles in the pathophysiology of lung cancer and because of its might be considered as a useful screening tool among the other markers in lung cancer diagnosis.
引用
收藏
页码：109 / 115
页数：7
相关论文
共 50 条
  • [41] The evaluation of soluble Fas and soluble Fas ligand levels of bronchoalveolar lavage fluid in lung cancer patients
    Erdogan, Beril
    Uzaslan, Esra
    Budak, Ferah
    Karadag, Mehmet
    Ediger, Dane
    Oral, Barbaros
    Goral, Gher
    Ege, Ercument
    Gozu, Oktay
    TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX, 2005, 53 (02): : 127 - 131
  • [42] The Diagnostic And Prognostic Value Of Serum Adenosine Deaminase Levels In Head And Neck Cancer
    Ashok, K. J.
    Pinto, G. J. O.
    Kavitha, A. K.
    Palathra, M. J.
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2008, 2 (03) : 833 - 837
  • [43] Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer
    Dornagafa-Kulawik, J
    Hoser, G
    Safianowska, A
    Grubek-Jaworska, H
    Chazan, R
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2006, 54 (02) : 143 - 147
  • [44] CLINICAL UTILITY OF HYALURONIC-ACID VALUES IN SERUM AND BRONCHOALVEOLAR LAVAGE FLUID AS TUMOR-MARKER FOR BRONCHOGENIC-CARCINOMA
    HERNANDEZ, JRH
    GARCIA, JMG
    MUNIZ, MAM
    MONCLUS, MTA
    MORELL, AR
    INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 1995, 10 (03) : 149 - 155
  • [45] Evaluation of cytokines in the tumor microenvironment of lung cancer using bronchoalveolar lavage fluid analysis
    Pascal Bezel
    Alan Valaperti
    Urs Steiner
    Dieter Scholtze
    Stephan Wieser
    Maya Vonow-Eisenring
    Andrea Widmer
    Benedikt Kowalski
    Malcolm Kohler
    Daniel P. Franzen
    Cancer Immunology, Immunotherapy, 2021, 70 : 1867 - 1876
  • [46] BRONCHOALVEOLAR LAVAGE FLUID FINDINGS FOLLOWING RADIOTHERAPY FOR NONSMALL CELL LUNG-CANCER
    MAASILTA, P
    HALLMAN, M
    TASKINEN, E
    KIVISAARI, L
    MATTSON, K
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 26 (01): : 117 - 123
  • [47] NITRITE/NITRATE AND CYTOKINE LEVELS IN BRONCHOALVEOLAR LAVAGE FLUID OF LUNG-CANCER PATIENTS
    ARIASDIAZ, J
    VARA, E
    TORRESMELERO, J
    GARCIA, C
    BAKI, W
    RAMIREZARMENGOL, JA
    BALIBREA, JL
    CANCER, 1994, 74 (05) : 1546 - 1551
  • [48] Cytokines in bronchoalveolar lavage fluid and serum of lung cancer patients during radiotherapy - Association of interleukin-8 and VEGF with survival
    Crohns, Marika
    Saarelainen, Seppo
    Laine, Seppo
    Poussa, Tuija
    Alho, Hannu
    Kellokumpu-Lehtinen, Pirkko
    CYTOKINE, 2010, 50 (01) : 30 - 36
  • [49] T-cell subtypes in bronchoalveolar lavage fluid and in peripheral blood from patients with primary lung cancer
    Domagala-Kulawik, J
    Hoser, G
    Droszcz, P
    Kawiak, J
    Droszcz, W
    Chazan, R
    DIAGNOSTIC CYTOPATHOLOGY, 2001, 25 (04) : 208 - 213
  • [50] Proteomic Analysis of the Air-Way Fluid in Lung Cancer. Detection of Periostin in Bronchoalveolar Lavage (BAL)
    Zhou, Yangying
    Yang, Weiming
    Ao, Minghui
    Hoti, Naseruddin
    Gabrielson, Edward
    Chan, Daniel W.
    Zhang, Hui
    Li, Qing Kay
    FRONTIERS IN ONCOLOGY, 2020, 10
12345