An overview of proteomic and metabolomic technologies and their application to pregnancy research

被引：54
作者：
Horgan, R. P. [1 ,2 ,3 ]
Clancy, O. H. [1 ,2 ]
Myers, J. E. [1 ,2 ]
Baker, P. N. [1 ,2 ]
机构：
[1] Univ Manchester, St Marys Hosp, Maternal & Fetal Hlth Res Ctr, Manchester M13 0JH, Lancs, England
[2] Univ Manchester, Manchester Interdisciplinary Bioctr, Bioanalyt Sci Grp, Manchester Ctr Integrat Syst Biol,Sch Chem, Manchester M13 0JH, Lancs, England
[3] Natl Univ Ireland Univ Coll Cork, Cork Univ Matern Hosp, Dept Obstet & Gynaecol, Cork, Cork, Ireland
来源：
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2009年 / 116卷 / 02期
关键词：
Metabolomics; proteomics; pregnancy; research; technology; MASS-SPECTROMETRY; FUNCTIONAL PROTEOMICS; BIOMARKER DISCOVERY; CLINICAL PROTEOMICS; PROTEINS; IDENTIFY; STRATEGIES; RELEVANT; PLACENTA; PROMISE;
D O I：
10.1111/j.1471-0528.2008.01997.x
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
'Omic' technologies represent a strategy towards high-throughput, simultaneous analysis of thousands of biological molecules. Their development has been accelerated in the post-genomic era since these molecules represent the interaction of genes and environment or the 'functional genome'. Omic domains are of particular interest in the search for predictive disease biomarkers and have additional relevance in understanding pathophysiology and the development of molecularly targeted therapeutics. This review examines the fields of proteomics and metabolomics in the context of obstetrics and gynaecology, including a discussion of methodology, challenges, potential applications and current research.
引用
收藏
页码：173 / 181
页数：9
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