UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

被引：12
作者：
Green, Luke [1 ,2 ]
Livingstone, Keith [1 ]
Bertrand, Sophie [2 ]
Peace, Simon [2 ]
Jamieson, Craig [1 ]
机构：
[1] Univ Strathclyde, Dept Pure & Appl Chem, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland
[2] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 65期
基金：
英国工程与自然科学研究理事会;
关键词：
flow; heterocycles; Huisgen reaction; nitrile imines; photochemistry; THERMAL-DECOMPOSITION; NITRILE IMINES; DERIVATIVES; SELECTIVITY; LIGHT;
D O I：
10.1002/chem.202002896
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.
引用
收藏
页码：14866 / 14870
页数：5
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