Pathological effects of the renin-angiotensin system on cardiovascular disease

被引：0

作者：

Zhang, Yan ^{[1
]}

机构：

[1] Luohe Med Coll, Luohe 462000, Peoples R China

来源：

PROCEEDINGS OF THE 2015 INTERNATIONAL CONFERENCE ON SOCIAL SCIENCE AND TECHNOLOGY EDUCATION (ICSSTE 2015) | 2015年 / 18卷

关键词：

renin - angiotensin system; angiotensin-converting enzyme 2; cardiovascular disease;

D O I：

暂无

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

the renin - angiotensin system (RAS) found in a research as a new member, changes the past view that only the angiotensin (Ang). catalyzed by angiotensin-converting enzyme (ACE) can produce pathogenic role. The research proved the renin binding with former prime renin - receptor (RPR) and Ang. binding with insulin receptor regulated aminopeptidase (IRAP) will also produce the same pathogenic role. The newly discovered ACE2 catalyzes Ang- (1-7) and Ang- (1-9) generation, then the receptor of Ang- (1-7) and Mas and the receptor of Ang- (1-9) and AT2 binding, may produce cardiovascular protective effect, but the pathogenic role of RAS is still dominant. The discovery of RAS new member provides a new theoretical basis to recognize RAS inhibitors in clinical research results.

引用

页码：58 / 60

页数：3