Physiology of freezing of gait

被引：147

作者：

Snijders, Anke H. ^{[1
,2
]}

Takakusaki, Kaoru ^{[3
]}

Debu, Bettina ^{[4
]}

Lozano, Andres M. ^{[5
]}

Krishna, Vibhor ^{[5
,6
]}

Fasano, Alfonso ^{[7
,8
]}

Aziz, Tipu Z. ^{[9
]}

Papa, Stella M. ^{[10
]}

Factor, Stewart A. ^{[10
]}

Hallett, Mark ^{[11
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol, Nijmegen, Netherlands

[2] Maasziekenhuis Pantein, Boxmeer, Netherlands

[3] Asahikawa Med Univ, Res Ctr Brain Funct & Med Engn, Asahikawa, Hokkaido, Japan

[4] Grenoble Univ, Joseph Fourier Univ, Grenoble, France

[5] Univ Toronto, Div Neurosurg, Toronto, ON, Canada

[6] Ohio State Univ, Dept Neurosurg, Columbus, OH 43210 USA

[7] Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Ctr, Toronto, ON, Canada

[8] Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Univ Hlth Network, Toronto, ON, Canada

[9] John Radcliffe Hosp, Oxford, England

[10] Emory Univ, Sch Med, Dept Neurol, Jean & Paul Amos Parkinsons Dis & Movement Disord, Atlanta, GA 30322 USA

[11] Natl Inst Neurol Disorders & Stroke, Human Motor Control Sect, NIH, Bethesda, MD USA

来源：

ANNALS OF NEUROLOGY | 2016年 / 80卷 / 05期

基金：

日本学术振兴会;

关键词：

DEEP BRAIN-STIMULATION; PEDUNCULOPONTINE NUCLEUS STIMULATION; PROGRESSIVE SUPRANUCLEAR PALSY; POSTURAL MUSCLE TONE; BASAL GANGLIA DYSFUNCTION; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; TEGMENTAL NUCLEUS; FREQUENCY STIMULATION; RETICULAR-FORMATION;

D O I：

10.1002/ana.24778

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Freezing of gait (FOG) is a common and debilitating, but largely mysterious, symptom of Parkinson disease. In this review, we will discuss the cerebral substrate of FOG focusing on brain physiology and animal models. Walking is a combination of automatic movement processes, afferent information processing, and intentional adjustments. Thus, normal gait requires a delicate balance between various interacting neuronal systems. To further understand gait control and specifically FOG, we will discuss the basic physiology of gait, animal models of gait disturbance including FOG, alternative etiologies of FOG, and functional magnetic resonance studies investigating FOG. The outcomes of these studies point to a dynamic network of cortical areas such as the supplementary motor area, as well as subcortical areas such as the striatum and the mesencephalic locomotor region including the pedunculopontine nucleus (PPN). Additionally, we will review PPN (area) stimulation as a possible treatment for FOG, and ponder whether PPN stimulation truly is the right step forward. Ann Neurol 2016;80:644-659

引用

页码：644 / 659

页数：16

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