Synthesis of the unnatural amino acid Nα-Nε-(ferrocene-1-acetyl)-L-lysine:: A novel organometallic nuclease

被引：23

作者：

Gellett, Amanda M. ^{[1
]}

Huber, Paul W. ^{[2
]}

Higgins, Pamela J. ^{[1
]}

机构：

[1] Dickinson Coll, Dept Chem, Carlisle, PA 17013 USA

[2] Univ Notre Dame, Dept Biochem & Chem, Notre Dame, IN 46556 USA

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2008年 / 693卷 / 18期

关键词：

bioorganometallic chemistry; ferrocene amino acid; coupling; chemical nuclease;

D O I：

10.1016/j.jorganchem.2008.06.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of a new unnatural amino acid, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine, was achieved by coupling a ferroceneacetic acid molecule onto the side chain amine of a lysine. The structure of the compound provides options for incorporation of the molecule into peptides or large proteins. In addition, N-alpha-N-epsilon-(ferrocene-1-acetyl)-L-lysine exhibits nuclease activity. It is expected that incorporation of this ferrocenyl amino acid into any nucleic acid-binding protein will endow the protein with nuclease capability. (C) 2008 Elsevier B. V. All rights reserved.

引用

收藏

页码：2959 / 2962

页数：4

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