Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story

被引:103
作者
Siracusano, Alessandra [1 ]
Delunardo, Federica [2 ]
Teggi, Antonella [3 ]
Ortona, Elena [2 ]
机构
[1] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, I-00161 Rome, Italy
[2] Ist Super Sanita, Dipartimento Biol Cellulare & Neurosci, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Osped St Andrea, Dipartimento Malattie Infett & Tropicali, I-00189 Rome, Italy
来源
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年
关键词
GRANULOSUS ANTIGEN-B; DENDRITIC CELL-DIFFERENTIATION; BLOOD MONONUCLEAR-CELLS; HYDATID-DISEASE; LARVAL STAGE; IMMUNOLOGICAL CHARACTERIZATION; PROTEOMIC ANALYSIS; IMMUNE-RESPONSE; FLUID ANTIGENS; FINE-STRUCTURE;
D O I
10.1155/2012/639362
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The larval stage of Echinococcus granulosus causes cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system, E. granulosus modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite. In vitro and in vivo immunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation of E. granulosus infection and the consequent induction and regulation of the immune response. Although the last decade has clarified many aspects of host-parasite relationship in human cystic echinococcosis, establishing the full mechanisms that cause the disease requires more studies. Here, we review some of the recent developments and discuss new avenues in this evolving story of E. granulosus infection in man.
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页数:12
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