Myelomatous Pleural Effusion in a Patient With Plasmablastic Myeloma: A Case Report

被引：18

作者：

Chang, Hung ^{[1
]}

Chou, Wen-Chi ^{[2
]}

Lee, Shen-Yang ^{[3
]}

Huang, Jeng-Yi ^{[3
]}

Hung, Yu-Hsin ^{[1
]}

机构：

[1] Chang Gung Univ, Div Hematol Oncol, Chang Gung Mem Hosp, Taipei, Taiwan

[2] St Pauls Hosp, Dept Internal Med, Tao Yuan, Taiwan

[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Nephrol, Taipei, Taiwan

来源：

DIAGNOSTIC CYTOPATHOLOGY | 2009年 / 37卷 / 03期

关键词：

multiple myeloma; plasmablast; IgD isotype; pleural effusion; immunophenotypes; MULTIPLE-MYELOMA;

D O I：

10.1002/dc.21004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Myelomatous pleural effusion is an unusual clinical condition associated with poor outcomes. We report a case with myelomatous pleural effusion upon the presentation of the disease. The patient had multiple risk factors for inferior prognosis of multiple myeloma, including old age, immunoglobulin D (IgD) iso-type, high lacatate dehydrogenase, C-reactive protein, beta 2-microglogulin levels, and a high myeloma cell burden in the bone marrow. The myeloma cells in both bone marrow and pleural effusion had characterisitcs features of plasmablasts, including gigantic size, large and eccentrically placed nuclei, fine cytoplasm, and prominent nucleoli. Immunophenotypical, both kappa and lambda light chains but negative for surface CD19 of CD79a. Our experience suggests that the diagnosis of myelomatous pleural effusion should be made with clinical alertness and careful cytological examination, preferably supplemented by immunophenotypical analysis. Diagn. Cytopathol. 2009;37:205-207 (C) 2009 Wiley-Liss. Inc.

引用

页码：205 / 207

页数：3

共 12 条

[1] IMMUNOGLOBULIN-D MULTIPLE-MYELOMA - PRESENTING FEATURES, RESPONSE TO THERAPY, AND SURVIVAL IN A SERIES OF 53 CASES [J].