Future of Chondroprotectors in the Treatment of Degenerative Processes of Connective Tissue

被引：17
作者：
Sukhikh, Stanislav [1 ,2 ]
Babich, Olga [1 ,3 ]
Prosekov, Alexander [3 ]
Patyukov, Nikolai [1 ]
Ivanova, Svetlana [4 ,5 ]
机构：
[1] Immanuel Kant Baltic Fed Univ, Inst Living Syst, A Nevskogo St 14, Kaliningrad 236016, Russia
[2] Kemerovo State Univ, Dept Bionanotechnol, Krasnaya St 6, Kemerovo 650043, Russia
[3] Kemerovo State Univ, Lab Biocatalysis, Krasnaya St 6, Kemerovo 650043, Russia
[4] Kemerovo State Univ, Nat Nutraceut Biotesting Lab, Krasnaya St 6, Kemerovo 650043, Russia
[5] Kemerovo State Univ, Dept Gen Math & Informat, Krasnaya St 6, Kemerovo 650043, Russia
来源：
PHARMACEUTICALS | 2020年 / 13卷 / 09期
基金：
俄罗斯基础研究基金会;
关键词：
osteoarthritis; chondroprotectors; treatment; collagen; chondrocytes; hyaluronic acid; VITAMIN-D SUPPLEMENTATION; PLATELET-RICH PLASMA; CELL-BASED THERAPY; KNEE OSTEOARTHRITIS; INTRAARTICULAR INJECTION; HYALURONIC-ACID; DOUBLE-BLIND; PAIN; METAANALYSIS; GLUCOSAMINE;
D O I：
10.3390/ph13090220
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Osteoarthritis is one of the most common diseases of the connective tissue of the elderly. It was found that most epidemiological studies used the Kellgren and Lawrence system for classification of osteoarthritis, which indicates one of the 5 degrees (0-4) of osteoarthritis in various joints according to the radiographic atlas. It has been proven that chondroprotectors are represented by the following active substances: chondroitin sulfate, glucosamine sulfate or hydrochloride, hyaluronic acid, glycosaminoglycans, extraction preparations from animal or plant raw materials. The sources of raw materials for the manufacture of combined chondroprotectors are known, methods for their preparation and use are described. The main drugs on the chondroprotective market are presented. The effectiveness of their use for the treatment of osteoarthritis has been proven. It was found that preparations containing chondroitin sulfate have anti-inflammatory activity, affecting mainly the cellular component of inflammation, stimulate the synthesis of hyaluronic acid and proteoglycans. Methods of treating osteoarthritis using cell therapy (the use of readily available, highly proliferative, and multipotent mesenchymal stromal cells) are presented.
引用
收藏
页码：1 / 14
页数：14
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