Aptamer-Directed Synthesis of Multifunctional Lanthanide-Doped Porous Nanoprobes for Targeted Imaging and Drug Delivery

被引：22

作者：

Zhou, Li ^{[1
,2
,3
]}

Li, Zhenhua ^{[1
,2
,3
]}

Ju, Enguo ^{[1
,2
,3
]}

Liu, Zhen ^{[1
,2
,3
]}

Ren, Jinsong ^{[1
,2
,3
]}

Qu, Xiaogang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resources Utilizat, Changchun 130022, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 24期

基金：

中国国家自然科学基金;

关键词：

lanthanides; aptamers; targeted imaging; drug delivery; nanoprobes; UP-CONVERSION NANOPARTICLES; CONTRAST AGENTS; FLUORESCENT NANOPARTICLES; INORGANIC NANOPARTICLES; STRUCTURAL POLYMORPHISM; PHOTODYNAMIC THERAPY; NAYF4; NANOCRYSTALS; OPTICAL-PROPERTIES; MEDIATED SYNTHESIS; CANCER CELLS;

D O I：

10.1002/smll.201301239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multifunctional lanthanide-doped porous nanoparticles are prepared via a facile one-step solvothermal route by employing aptamers as the biotemplate. The nanoparticles feature excellent aqueous dispersibility and biospecific properties and could work as effective nanoprobes for targeted imaging and drug delivery. With aptamer being in principle available for any kind of target, this synthetic strategy may open the door to a new generation of nanoprobes for bioapplications such as time-resolved biodetection, multimode bioimaging/biolabeling, and targeted cancer therapy.

引用

页码：4262 / 4268

页数：7

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