Inhibition of the Renin-Angiotensin-Aldosterone System for Cerebrorenal Protection

被引：2

作者：

Heerspink, H. J. Lambers ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharmacol, NL-9713 AV Groningen, Netherlands

来源：

BRAIN, STROKE AND KIDNEY | 2013年 / 179卷

关键词：

DIETARY-SODIUM RESTRICTION; CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE; CARDIOVASCULAR OUTCOMES; HYPERTENSIVE PATIENTS; ALISKIREN TRIAL; ACE-INHIBITION; STROKE; MORTALITY; TELMISARTAN;

D O I：

10.1159/000346717

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood pressure is a strong risk factor for ischemic and atherosclerotic events such as stroke. Blood pressure is often elevated in patients with chronic kidney disease. Consequently, chronic kidney disease patients are at high risk of developing cardiovascular and cerebrovascular damage. Blood pressure reduction by means of inhibiting the renin-angiotensin-aldosterone system (RAAS) reduces the risk of stroke. There is evidence available in the primary and secondary prevention of stroke that RAAS blockade exerts cerebrovascular protective effects independent of blood pressure lowering. This chapter discusses the role of RAAS blockade for the prevention and treatment of stroke in chronic kidney disease. The role of dual RAAS blockade will be reviewed and alternative strategies to enhance the effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers will be provided. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：7 / 14

页数：8

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