Comparison of Factors Associated with Carotid Intima-Media Thickness in the Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR)

被引:23
作者
Bauer, Marcus [1 ,8 ]
Delaney, Joseph A. C. [3 ,4 ]
Moehlenkamp, Stefan [1 ]
Joeckel, Karl-Heinz [2 ]
Kronmal, Richard A. [3 ]
Lehmann, Nils [2 ]
Mukamal, Kenneth J. [5 ]
Moebus, Susanne [2 ]
Polak, Joseph F. [6 ,7 ]
Dragano, Nico [2 ]
Budoff, Matthew J.
Erbel, Raimund [1 ]
McClelland, Robyn L. [3 ]
机构
[1] Univ Duisburg Essen, Dept Cardiol, Essen, Germany
[2] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany
[3] Univ Washington, Seattle, WA 98195 USA
[4] Univ Florida, Gainesville, FL USA
[5] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA
[6] Tufts Med Ctr, Dept Radiol, Boston, MA USA
[7] Tufts Med Ctr, Ctr Cardiovasc, Boston, MA USA
[8] Harbor UCLA BioMed CT Reading Ctr, Torrance, CA USA
基金
美国国家卫生研究院;
关键词
Carotid intima-media thickness; Subclinical atherosclerosis; Multi-Ethnic Study of Atherosclerosis; MESA; Heinz Nixdorf Recall Study; HNR; CORONARY-ARTERY CALCIFICATION; ALCOHOL-CONSUMPTION; MYOCARDIAL-INFARCTION; HEART-DISEASE; RISK-FACTORS; BEER; WINE; METAANALYSIS; PROGRESSION; POPULATION;
D O I
10.1016/j.echo.2013.03.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The measurement of carotid intima-media thickness (CIMT) is a valid method to quantify levels of atherosclerosis. The present study was conducted to compare the strengths of associations between CIMT and cardiovascular risk factors in two different populations. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR) are two population-based prospective cohort studies of subclinical cardiovascular disease. All Caucasian subjects aged 45 to 75 years from these cohorts who were free of baseline cardiovascular disease (n = 2,820 in HNR, n = 2,270 in MESA) were combined. CIMT images were obtained using B-mode sonography at the right and left common carotid artery and measured 1 cm starting from the bulb. Results: In both studies, age, male sex, and systolic blood pressure showed the strongest association (P < .0001 for each) for a higher CIMT. The mean of mean far wall CIMT was slightly higher in MESA participants (0.71 vs 0.67 mm). Almost all significant variables were consistent between the two cohorts in both magnitude of association with CIMT and statistical significance, including age, sex, smoking, diabetes, cholesterol levels, and blood pressure. For example, the association with systolic blood pressure was (Delta SD = 0.011; 95% confidence interval, 0.0009 to 0.014) per mm Hg in MESA and (Delta SD = 0.010; 95% confidence interval, 0.005 to 0.021) per mm Hg in HNR. This consistency persisted throughout the traditional (Framingham) risk factors. Conclusions: A comparison of the associations between traditional cardiovascular risk factors and CIMT across two culturally diverse populations showed remarkable consistency.
引用
收藏
页码:667 / 673
页数:7
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