Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.

被引：18

作者：

Meng, Qinghong ^{[1
,2
]}

Fan, Jiajia ^{[2
]}

Liu, Zhiguo ^{[2
]}

Li, Xiwen ^{[2
]}

Zhang, Fangbo ^{[2
]}

Zhang, Yanlin ^{[1
,2
]}

Sun, Yi ^{[2
]}

Li, Li ^{[3
,4
]}

Liu, Xia ^{[5
]}

Hua, Erbing ^{[1
]}

机构：

[1] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China

[2] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100010, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100010, Peoples R China

[4] Peking Union Med Coll, Beijing 100010, Peoples R China

[5] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China

来源：

MOLECULES | 2019年 / 24卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Solanaceae; Physalis angulata L; withanolides; cytotoxic activities; CONSTITUENTS; PLANTS; STEROIDS; MINIMA;

D O I：

10.3390/molecules24081608

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding techniques. Two new withanolides (1-2), together with six known analogues (3-8), were isolated from the whole plant of Physalis angulata L. The structures of these new compounds were determined on the basis of extensive spectroscopic data analyses and electronic circular dichroism (ECD) calculations. The withanolides exhibited strong cytotoxic activities against A549, Hela and p388 cell lines. Furthermore, compounds 1 and 2 induced typical apoptotic cell death in A549 cell line according to the evaluation of the apoptosis-inducing activity by flow cytometric analysis.

引用

页数：9

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