Alteration of biochemical profiles after high-dose intravenous immunoglobulin administration in Kawasaki disease

被引：13

作者：

Lee, KY ^{[1
]}

Han, JW ^{[1
]}

Lee, JS ^{[1
]}

Whang, KT ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Pediat, Seoul, South Korea

来源：

ACTA PAEDIATRICA | 2002年 / 91卷 / 02期

关键词：

HDL-cholesterol; intravenous immunoglobulin; Kawasaki disease; lipids; proteins;

D O I：

10.1080/080352502317285153

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Intravenous immunoglobulin (IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. Early effects of high-dose IVIG treatment on biochemical profiles including lipids and proteins were evaluated in patients with Kawasaki disease (KD). Twelve children with KID (9 boys) were treated with IVIG at 2 g/kg over a period of 12 h. Serial sera samples were collected from the patients four times: before IVIG treatment and 2 h, 24 h and 7 d after IVIG treatment. The samples were frozen at -20degreesC before biochemical analysis. A significant decrease in albumin concentration was found 2 h and 24 h after IVIG treatment, but this recovered to the pretreatment level after 7 d. Total cholesterol and triglyceride increased slightly after 7 d. A significant decrease in HDL-cholesterol and C-reactive protein was seen 2 h and 24 h after IVIG treatment. Conclusion: High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.

引用

页码：164 / 167

页数：4

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